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Name: Isotretinoin / Accutane

 

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Buy Accutane - Information

 

Accutane Indications And Usage: Severe Recalcitrant Nodular Acne. Accutane is indicated for the treatment of severe recalcitrant nodular acne. Nodules are inflammatory lesions with a diameter of 5 mm or greater. The nodules may become suppurative or hemorrhagic. Severe, by definition, means many as opposed to few or several nodules. Because of significant adverse effects associated with its use, Accutane should be reserved for patients with severe nodular acne who are unresponsive to conventional therapy, including systemic antibiotics. In addition, Accutane (Isotretinoin) is indicated only for those female patients who are not pregnant, because Accutane can cause severe birth defects.

 

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A single course of therapy for 15 to 20 weeks has been shown to result in complete and prolonged remission of disease in many patients. If a second course of therapy is needed, it should not be initiated until at least 8 weeks after completion of the first course, because experience has shown that patients may continue to improve while off Accutane. The optimal interval before retreatment has not been defined for patients who have not completed skeletal growth.

 

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Accutane should be administered with a meal. The recommended dosage range for Accutane is 0.5 to 1 mg/kg/day given in two divided doses with food for 15 to 20 weeks. Once daily dosing is not recommended. In studies comparing 0.1, 0.5 and 1 mg/kg/day, it was found that all dosages provided initial clearing of disease, but there was a greater need for retreatment with the lower dosages. During treatment, the dose may be adjusted according to response of the disease and/or the appearance of clinical side effects - some of which may be dose related. Adult patients whose disease any conjugates are ultimately excreted in the feces and urine in relatively equal amounts (total of 65% to 83%).

 

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Isotretinoin (Accutane) is a medicine that revolutionized the treatment of acne. Accutane belongs to the family of medicines called retinoids, which are similar to vitamin A. Accutane, like other retinoids, works by altering DNA transcription. This affect decreases the size and output of sebaceous glands. It also makes the cells that are sloughed off into the sebaceous glands less sticky, and therefore less able to form blackheads and whiteheads (comedones). It also reduces the number of bacteria in the sebaceous gland and on the skin surface.

 

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The most common, less serious adverse events include dry skin, chapped lips, dry eyes, and dry nose that may lead to nosebleeds. Patients should be advised about these adverse events and routinely monitored by a doctor during treatment with Accutane. Refer to the Accutane package inserts for full prescribing and dispensing instructions.

 

Average Dosage: 0.5 to 1.0 mg/kg/day

 

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