Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Incidence not known- Agitation
- back, leg, or stomach pains
- black, tarry stools
- bleeding gums
- chest pain
- chills
- clay-colored stools
- confusion
- cough
- dark urine
- diarrhea
- difficulty in breathing or swallowing
- dizziness
- fast heartbeat
- fever
- general body swelling
- headache
- hives, itching, skin rash
- loss of appetite
- nausea
- nosebleed
- painful or difficult urination
- pale skin
- poor coordination
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- redness of the skin
- restlessness
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- stomach pain
- sweating
- swelling of the face, throat, or tongue
- swollen glands
- talking or acting with excitement you cannot control
- tightness in the chest
- trembling or shaking
- twitching
- unpleasant breath odor
- unusual bleeding or bruising
- unusual tiredness or weakness
- vomiting
- vomiting of blood
- yellowing of the eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common- Drowsiness
- irritability
- stomach or bowel upset
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Skelaxin should be administered with great care to patients with pre-existing liver damage. Serial liver function studies should be performed in these patients. False-positive Benedict's tests, due to an unknown reducing substance, have been noted. A glucose-specific test will differentiate findings. Taking Skelaxin with food may enhance general CNS depression; elderly patients may be especially susceptible to this CNS effect.
Driving or Operating Heavy MachinerySkelaxin may impair mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle, especially when used with alcohol or other CNS depressants.
Serotonin Syndrome.Cases of serotonin syndrome, a potentially life-threatening condition, have been reported during concomitant use of serotonergic drugs with Skelaxin used within the recommended dosage range and with Skelaxin as a single agent taken at doses higher than the recommended dose. Serotonergic drugs include selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, opioids (particularly fentanyl, meperidine, and methadone), drugs that affect the serotonergic neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), and drugs that impair metabolism of serotonin (including monoamine oxidase (MAO) inhibitors, both those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue).
Serotonin syndrome symptoms may include mental status changes (e.g., agitation, hallucinations, coma), autonomic instability (e.g., tachycardia, labile blood pressure, hyperthermia), neuromuscular aberrations (e.g., hyperreflexia, incoordination, rigidity), and/or gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea). The onset of symptoms generally occurs within several hours to a few days, but may occur later than that. Discontinue Skelaxin if serotonin syndrome is suspected.
Risks from Concomitant Use with Alcohol or other CNS DepressantsThe sedative effects of Skelaxin and other CNS depressants (e.g., alcohol, benzodiazepines, opioids, tricyclic antidepressants (TCAs)) may be additive. Exercise caution with patients who take more than one of these CNS depressants simultaneously. Follow patients closely for signs and symptoms of respiratory depression and sedation.
The sedative effects of Skelaxin and other CNS depressants (e.g., alcohol, benzodiazepines, opioids, tricyclic antidepressants (TCAs)) may be additive. Exercise caution with patients who take more than one of these CNS depressants simultaneously. Follow patients closely for signs and symptoms of respiratory depression and sedation.
Serotonergic DrugsSerotonin syndrome has resulted from concomitant use of serotonergic drugs with Skelaxin used within the recommended dosage range. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Discontinue Skelaxin if serotonin syndrome is suspected.
Examples of serotonergic drugs include: selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, opioids (particularly fentanyl, meperidine, and methadone), drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue).
Reproduction studies in rats have not revealed evidence of impaired fertility or harm to the fetus due to metaxalone. Post marketing experience has not revealed evidence of fetal injury, but such experience cannot exclude the possibility of infrequent or subtle damage to the human fetus. Safe use of metaxalone has not been established with regard to possible adverse effects upon fetal development. Therefore, metaxalone tablets should not be used in women who are or may become pregnant and particularly during early pregnancy unless, in the judgement of the physician, the potential benefits outweigh the possible hazards.
Nursing MothersIt is not known whether this drug is secreted in human milk. As a general rule, nursing should not be undertaken while a patient is on a drug since many drugs are excreted in human milk.
Buy Skelaxin online
Where can I buy Skelaxin without prescription?Metaxalone is a prescription drug that comes in 800mg tablets. It is available on prescription only as tablets for oral use, but the online pharmacy, will sell Metaxalone without prescription. You may be able to order Skelaxin from them online and save the local pharmacy markup. One way of buying Skelaxin without prescription is to order Metaxalone 800mg from an online pharmacy. Usually, you can buy generic Skelaxin online with overnight delivery and with no RX required.
Skelaxin
Generic name
Metaxalone
Chemical class
Skeletal Muscle Relaxants
800 mg orally every 6-8 hours
Children 12 years and older
800 mg orally every 6-8 hours
Children under 12 years
Safety and efficacy not established