Isotretinoin belongs to a class of drugs called retinoids, which are synthetic derivatives of vitamin A. These drugs are used to treat severe acne and other skin conditions. Topical isotretinoin has been shown to be effective as a treatment in combination with other medications for oral lichen planus.
Because isotretinoin is derived from vitamin A, users of this drug should be careful to avoid vitamin A supplements, as this can cause dangerous side effects.
Original uses (on-label)
unresponsive to conventional therapy.
Newly discovered uses (off-label)
Also, patients can order isotretinoin online to treat leukoplakia, oral lichen planus, prevention of recurrence of oral cancer.
Potential side effects
The most common, less serious adverse events include dry skin, chapped lips, dry eyes, and dry nose that may lead to nosebleeds. Patients should be advised about these adverse events and routinely monitored by a doctor during treatment with Accutane. Refer to the Accutane package inserts for full prescribing and dispensing instructions.
- Notify your doctor if you are pregnant, are allergic to parabens, vitamin A, or other retinoids, have diabetes mellitus, increased triglyceride levels, or pancreatitis.
- Not for use during pregnancy. Requires two negative pregnancy tests; effective contraceptive used at least one month prior to starting therapy, during therapy, and for at least one month after discontinuing therapy, and prescriptions can only be written for one month supply at a time.
- Not to be used if you are a woman in childbearing age unless complying with effective contraceptive methods, and patients must commit to using two forms of birth control.
- Patients must be enrolled in the manufacturer sponsored and FDA approved monitoring programs.
- Depression, psychosis, aggressive or violent behavior, and rarely suicidal thoughts and actions have been reported during use.
- Patients who order Accutane need to understand that it use only for severe cystic acne that have not responded to less toxic drugs.
- Avoid excessive exposure to the wind, sun or cold temperatures. Retinoids may increase your skin's vulnerability to these conditions and may cause dryness and burning.
- Using this medication may make it difficult to wear contact lens because of the drying effect on the eyes.
Corticosteroids, phenytoin, tetracycline, carbamazepine.
Dosage And Administration
Accutane should be administered with a meal. The recommended dosage range for Accutane is 0.5 to 1 mg/kg/day given in two divided doses with food for 15 to 20 weeks. Once daily dosing is not recommended. In studies comparing 0.1, 0.5 and 1 mg/kg/day, it was found that all dosages provided initial clearing of disease, but there was a greater need for retreatment with the lower dosages. During treatment, the dose may be adjusted according to response of the disease and/or the appearance of clinical side effects - some of which may be dose related. Adult patients whose disease any conjugates are ultimately excreted in the feces and urine in relatively equal amounts (total of 65% to 83%).
Course of therapy
A single course of therapy for 15 to 20 weeks has been shown to result in complete and prolonged remission of disease in many patients. If a second course of therapy is needed, it should not be initiated until at least 8 weeks after completion of the first course, because experience has shown that patients may continue to improve while off Accutane. The optimal interval before retreatment has not been defined for patients who have not completed skeletal growth.
Pregnancy and breast-feeding cautions
FDA Pregnancy Risk Category X. Excretion in breast milk is unknown. Use during breast-feeding is not recommended.
Do not buy Accutane if you are pregnant or may become pregnant while undergoing therapy.
The chances are extremely high that the infant will be deformed if Accutane is used during pregnancy, or if pregnancy occurs while taking generic Accutane, in any amount, even for short periods of time.
Buy Accutane online
Where can I buy Accutane without prescription?
Isotretinoin is a prescription drug that comes in 5 mg, 10 mg, 20 mg, 30 mg tablets.
It is available on prescription only as tablets for oral use, but the online pharmacy, will sell Isotretinoin without prescription.
You may be able to order Accutane from them online and save the local pharmacy markup.
This drug has a black box warning describing the known teratogenic effects when taken during pregnancy.
In addition, it describes the restricted dispensing program that requires signed patient consent and counseling along with negative pregnancy tests prior to the initiation of therapy.
Additional information is also provided regarding the risk of suicidal ideation.
Read the complete patient brochure and discuss these risks with your doctor.
Isotretinoin (Accutane) is a medicine that revolutionized the treatment of acne. Accutane belongs to the family of medicines called retinoids, which are similar to vitamin A. Accutane, like other retinoids, works by altering DNA transcription. This affect decreases the size and output of sebaceous glands. It also makes the cells that are sloughed off into the sebaceous glands less sticky, and therefore less able to form blackheads and whiteheads (comedones). It also reduces the number of bacteria in the sebaceous gland and on the skin surface.
What is Accutane?
This drug reduces the size of fatty glands and reduces fat production. It also regulates cell proliferation and differentiation.
Brands & Classes
Acne product (vitamin A derivative)
Tablets - Oral 5 mg, 10 mg, 20 mg, 30 mg.
PO 0.5-2 mg/kg/day divided bid for 15-20 wk or until total cyst count decreases by 70%; a 2nd course may be initiated after ≥2 mo off therapy if warranted by persistent or recurring severe cystic acne.